Interestingly, recent research has suggested that use of metformin may protect against neurodegenerative diseases.
When asked about that, Dr Kuan told Medscape Medical News that "some studies have actually found positive [outcomes] but some have been negative." So the researchers wanted to look into this using their own data.
In addition, outcome risks increased progressively with higher dosage and longer duration of treatment.
The results were presented here at AD/PD 2017: The 13th International Conference on Alzheimer's and Parkinson's Diseases by Yi-Chun Kuan, MD, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
courtesy name Yunchang, was a general serving under the warlord Liu Bei in the late Eastern Han dynasty.
He played a significant role in the events that led to the collapse of the dynasty and the establishment of the state of Shu Han – founded by Liu Bei – in the Three Kingdoms period.
By the time Guan Yu found out about the loss of Jing Province after his defeat at Fancheng, it was too late.
He was subsequently captured in an ambush by Sun Quan's forces and executed.
In a cohort study that followed about 9300 patients with T2DM in Taiwan for up to 12 years, the risk for Parkinson's disease (PD) or Alzheimer's dementia was more than double during a 12-year period for those who took metformin vs those who did not — even after adjusting for multiple confounders.
So long as your virtuous conduct and courtesy never falter, there will be no one who does not cherish you.'" When Duke Huan was approached to dethrone the ruling clans of his state, Guan Zhong advised him that he had won their adherence through politeness (li) and trustworthiness (xin).
When Confucius's students criticized Guan Zhong as lacking propriety, Confucius said of him that "Through having Guan Zhong as his minister Duke Huan became protector over the feudal lords.
"We'd heard about a possible protective effect from metformin.
However, we found the reverse," she said, but stressed that large-scale, prospective studies in other countries are needed to clarify the results.